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Stem cells cloned from menstrual blood

A team of researchers from Canada and the United States has taken an important step toward harnessing the healing power of menstrual blood.

They used stem cells isolated from the menstrual blood of two women and cloned by a San Diego company to save the legs of eight severely injured mice.

University of Western Ontario surgeon Hao Wang injected the menstrual stem cells into mice that had had the blood vessels to their legs blocked and the nerves tied. The mice that received the injection immediately after they were injured recovered, although two of them limped. But the legs of the mice in the control group turned black and fell off after 10 days, Dr. Wang said. All of the mice in the experiment were male.

The findings, reported yesterday in the Journal of Translational Medicine, are preliminary, but offer a glimpse into the potential of stem cells derived from menstrual blood in treating human patients, male and female.

Thomas Ichim, CEO of Medistem Laboratories, the company that cloned the stem cells, is hoping they will prove to be an effective treatment for both men and women with a condition known as critical limb ischemia - serious obstruction of arteries that leads to decreased blood flow to hands, legs and feet. The condition causes 150,000 amputations a year in the United States.

Dr. Ichim is keen to begin a small human trial if he can get approval from the U.S. Food and Drug Administration and also hopes to investigate whether cells might also help people with multiple sclerosis and liver failure.

Dr. Ichim and one of the other authors of the paper, Neil Riordan, are both shareholders and managers at the publicly traded company. Dr. Wang and the other scientists are not shareholders. He says it is promising that the human stem cells worked so well in mice.

In the developing embryo, stem cells have an endless capacity for self-renewal and give rise to every type of cell in the body - skin, muscle, bone, heart, liver, kidney, brain and more than 250 other kinds of specialized cells. In adults, stem cells are far more rare, and provide the replacement cells to keep our bodies healthy and working well.

Scientists around the world are working to harness the regenerative power of stem cells to repair the human body.

Using embryonic stem cells is controversial because some come from aborted fetuses (some also come for umbilical cords). Many scientists are now trying to side step the ethical debate by reprogramming mature cells back to their embryonic state.

Getting stem cells from menstrual blood is another approach. The lining of the uterus is shed every month when a woman has her period. Research suggests the endometrium, or lining of the uterus, is rich in adult stem cells.

In 2007, researchers announced that cells taken from the menstrual blood of two women could be coaxed into becoming nine different types of cells, including muscle, nerve and bone.

It is those cells that Medistem Laboratories has cloned, Dr. Ichim said. The company calls them endometrial regenerative cells. The next step, said Dr. Wang, is to figure out exactly what these stem cells did to save the legs of the mice that had been injured.

It may be, Dr. Ichim said, that they produced growth factor that stimulated mouse stem cells to repair the damage.

How can I tell if my partner has sleep apnea?

We ask the experts to settle common questions we’ve all wondered about. If you’ve got a question, send it to seriously@globeandmail.com. Be sure to include your hometown and a daytime contact number so we can follow up with any queries.

QUESTION I hear my partner snoring at night and I am worried that it might be sleep apnea - how can I tell and what should we do?

ANSWER Although an overnight study performed at the sleep clinic by a medical professional is the most reliable way to determine whether someone suffers from obstructive sleep apnea, there are indicators of this condition that are frequently reported by sufferers or their sleeping partners. Snoring is one.

But not everyone who snores has OSA. OSA affects 2 to 5 per cent of people over 30 and is much less common than snoring, but there are similarities in these two conditions. Both snoring and sleep apnea occur more often in men than women (the ratio is 2:1) although this difference disappears after menopause.


From the archives

  • When should exercise be introduced into a stroke survivor’s recovery? 
  • Can you be asleep with your eyes open? 
  • Does plucking my nose hairs affect my sense of smell? 
  • Does washing your hair too often make you get dandruff or go bald? 

West Nile recovery takes a year: study

People who have contracted West Nile virus - even those with some serious neurological complications - can take heart that they will fully recover over time, Canadian researchers say.

In a study of 156 Canadians afflicted with West Nile virus disease, including some who developed potentially fatal meningitis and encephalitis, the average time to recovery was about a year, said principal investigator Mark Loeb, an infectious-disease specialist at McMaster University in Hamilton, Ont.

"If they’re infected with West Nile, where they have West Nile fever or they have West Nile virus meningitis or encephalitis, these data can tell them what to expect, that gradually over about a year their mental and physical function generally and on average will return to normal," Dr. Loeb said.

While there is always some variation among individual patients, Dr. Loeb said, "I think at least it helps patients and physicians and their families to know what to expect over time."

Health workers urged to fight their own bias about mental illness

MONTREAL — Some of the worst discrimination and stigma faced by people suffering from mental illness comes from their health-care providers, the chairman of the Mental Health Commission of Canada says.

Michael Kirby exhorted Canada’s doctors yesterday to "demonstrate a commitment to healing" by tackling head-on the myths and stereotypes about people with mental illness.

"I challenge you to help us change public attitudes, to help reduce stigma and discrimination. You can play an invaluable role in improving the lives of people living with mental illness by becoming a community leader on the stigma issue," he said in an address to the 141st annual meeting of the Canadian Medical Association, taking place this week in Montreal.

The Mental Health Commission of Canada, created last year, has among its priorities the development of a national mental-health strategy and a long-term stigma-reduction campaign.


Recent

  • Stigma of mental illness pervasive: CMA head 

Chewing gum to promote healing?

LONDON — Chewing gum after colon surgery appears to speed up the return of normal bowel function, British researchers said on Monday.

Postoperative ileus – the inability of the intestines to pass contents – is a common result of abdominal surgery, causing pain and potential health complications.

Chewing a few sticks of gum, however, could be an effective and low-cost solution.

Sanjay Purkayastha and colleagues at St. Mary’s Hospital, London, analyzed data from five trials involving 158 patients in which some patients chewed sugarless gum three times a day.

They found patients who chewed gum took an average of 1.1 fewer days to have a bowel movement compared with non-chewers.

Gum chewing is thought to act as a kind of "sham feeding," stimulating nerves in the digestive system, triggering the release of gastrointestinal hormones and increasing the production of saliva and secretions from the pancreas.

The researchers said further large-scale studies were needed to assess the true benefits of gum chewing on reducing ileus, a problem that is estimated to cost $1-billion a year in health-care expenditures in the United States alone.

Their findings were published in the journal Archives of Surgery.

Stigma of mental illness pervasive: CMA head

MONTREAL — Almost half of Canadians believe that a diagnosis of mental illness is merely an "excuse for poor behaviour and personal failings" and one in 10 thinks that people with mental illness could "just snap out of it if they wanted," according to the startling findings of a new opinion poll.

The survey, commissioned by the Canadian Medical Association, shows that the stigma of mental illness remains pervasive, making it the "final frontier of socially acceptable discrimination," Canada’s top doctor says.

Brian Day, a Vancouver orthopedic surgeon and president of the CMA, said the survey "shines a harsh, and frankly unflattering, light on the attitudes we Canadians have concerning mental health."

But he added that it is best to expose such views and tackle them head-on rather than allow stigma to fester. "It’s important that these data be out there and we discuss them," Dr. Day said.


Recent

  • Meditating through mental illness 

From the archives

  • Editor’s note: Speak your mind – and erase a stigma 

A doorstep diet could be just the one for you

Four writers with different eating dilemmas tried the latest home-delivery meal plans to see if they had an appetite for convenience

BODY CHEF

Richard McClure

Goal: At 15 stone, I wanted to take drastic action to prevent the onset of elasticated trousers and Type 2 diabetes. In particular, I wanted to stop snacking.

 

At your door: home-delivery meal plans are great for the time-poor

Good for: Busy people on a budget.

Price: £87 for two hampers containing enough food for a week.

The promise: “Not only will you turn your body shape around but you will also feel energised, improve skin tone, and potentially fight cellulite… and help your body fight diseases while you are losing weight.”

Consists of: Freshly prepared food arrived in chilled hampers with grim-looking plastic containers marked ‘Dinner One’ etc. Came with a photocopied weekly menu planner.

Flexibility: A range of menus is offered (eg, detoxing or weight loss) but it’s possible to customise each menu. As a fish eater, I chose the vegetarian menu, supplemented with salmon.

Practical positives: The hampers always arrived on time. The company will deliver to a home or work address. Cooking instructions were clear.

Feelgood factor: The diet got off to a bad start when my first breakfast consisted of a piece of sliced bread wrapped in clingfilm (for toasting). It looked as appetising as, well, a slice of bread in clingfilm.

Tasty evening meals included vegetable provençale with couscous, but generally the hamper’s contents were unimpressive and carb-heavy. And I’m not convinced that processed cheese triangles should be really part of any healthy eating plan.

The downside: The menu seemed at odds with nutrition or physical wellbeing. Many of the unimaginative items appeared to be grabbed off the shelves of the local Morrisons: a toddler-sized portion of Shreddies; a couple of Ryvita. The fruit and salads were doleful. Does anyone still eat grated carrot?

Did you cheat? How could I not? It often proved easier and more appetising for me to make my own food.

Results: It did help to make my eating habits more disciplined and introduced me to the idea of small, regular snacks during the day rather than my previous uncontrolled fridge-raiding.

 
Home-delivered low-fat meals have become increasingly sophisticated

Verdict: To be fair, if followed correctly, the diet should help people achieve weight loss. It simply wasn’t to my taste.

Contact: www.bodychef.com; 01502 581162

DETOX - IN A BOX

Genevieve Fox

Goal: To take control of my eating habits and to eat three meals a day; to detox; and to feel energised.

Bottoms up girls and mix your cocktails with cardio

A training programme targeted at the modern woman convinces Bryony Gordon to lace up her trainers and head for the park

If ever there was someone who understands how difficult it is for modern women to get fit and stay that way, that person is Georgie Thompson.

 

Bryony Gordon, left, gets a SuperChick workout

Springing down on to her knees for 20 effortless press-ups in the middle of Hyde Park, she admits that the previous night, after a training session, she went out and had a good few drinks.

“You have to balance your cardio with your cocktails,” she smiles, dropping into a lunge. Comforting words for women who, like me, want to let themselves live a little this summer, without going up two dress sizes.

By day, Thompson is a Sky Sports news presenter, but by night she runs SuperChick, a new fitness company that provides women with a free online personal training programme tailored to their needs.

Her aim is to motivate the estimated four in five females who do too little sport and exercise - a figure that the Women’s Sport and Fitness Foundation estimates will increase to 19 out of 20 by the year 2017.

As one whose only exercise at the best of times - let alone on holiday - is lifting a glass of wine to her lips, I definitely fit into that bracket. But Thompson doesn’t go in for the kind of ”evangelical” approach to fitness that usually makes me switch off.

“I know from my own experience that it is difficult to maintain a professional and a social life and squeeze in staying fit,” she says. “I was lucky to be able to afford a personal trainer, but it was getting pretty expensive. I thought ‘no wonder women are so uninspired’ - you either go to a gym full of sweaty blokes, and tentatively ask the staff how to use a medicine ball, or just muddle along by yourself before giving up.”

So Thompson got together with her personal trainer, Cat Dugdale, a former dancer, and they came up with the idea of creating an online library of exercise programmes - mixing resistance and cardiovascular training - just for women, and www.iamsuperchick.com was born. It currently has 3,500 members, in Britain, America and Australia.

 
And lunge: Bryony opted for the ‘Bridget’ programme

Users log in to a personal webpage. There they access their own fitness diary tailored to their needs and goals. Some are straightforward and encourage you to lose weight and tone up; others help you get fit for races from 5-km to marathon level.

There are also quirkier programmes such as the ”Bridget”, for women who smoke and drink too much, and ”City Rehab”, for those who work so hard they have only snatched moments to get fit.

Or how about trying the ”Break-Up - Wake-Up!”, for women who have recently ended a relationship? Mums who want to get their figures back are not ignored (inevitably, their programme is called ”Yummy Mummy”), and pregnant women are also included.

Naturally, I opt for the ”Bridget”, which involves training for 40 minutes four times a week, with a mixture of step-ups, squats, lunges and cardio to target “bingo wings and saggy bums”. “We wanted it to complement women’s lifestyles, not complicate them,” says Thompson. “The idea is that you can go anywhere in the world and access your training programme.” So it’s perfect for holidays: you only need a wireless connection and a local park or beach to keep up your regime.

Still, the prospect of training with a beautiful television presenter and a super-fit personal trainer is not one I particularly relish as I lace up my barely worn trainers. But when I lumpenly attempt a push-up - and fail - the pair neither tut nor patronise.

“You have good posture,” notes Dugdale, kindly - although possibly not entirely truthfully. Still, it gees me on and I manage to do not just one push-up, but 10, and I don’t feel at all silly when they make me squat over a park bench. They even get me running - kindly dropping their pace in deference to my wheezy, tar-stained lungs. After 40 minutes, I feel energised and inspired - not words I usually spit out at the end of a fitness session.

As a fully signed-up user, each week I will receive a motivational email plus electronic cupcakes for completing my tasks - although Thompson and Dugdale hope to turn these into real rewards, such as make-up, very soon. Every exercise is accompanied by user-friendly instructions and printable diagrams.

But it’s far from boring, because it’s balanced with recipes for healthy cocktails (this month’s feature is a tangerine and carrot martini - packed with beta-carotene, apparently) and food. Plus it catalogues the calorific content of every sandwich from Tesco, Sainsbury’s, Pret A Manger and even McDonald’s.

“I know time is paramount for people nowadays,” Thompson says, “and this allows you to work out what you want for lunch before you have even stepped out of the office.”

An alcohol counter also allows you to tot up your units, and balance out your Cosmopolitan intake with exercise - a prospect that this Bridget, booze-soaked from a recent holiday, finds slightly terrifying. However, it turns out to be motivational.

“We are realistic,” says Thompson. “We know you like a drink and that from time to time you want to indulge in rich food, and that’s fine with us as long as you create a balance.”

And with that, she jogs off - though not, she assures me, to the nearest cocktail bar.

HEALTH CLICKS

www.mapmyrun.com
Allows you to sketch out courses and connect with other runners across the globe. There is a forum to discuss injuries and share tips, and you can also create training programmes.

www.slimtree.com
Features a library of videos advising on exercises from yoga and pilates to martial arts and kickboxing - as well as quirky alternatives, such as cardio jazz dance.

uk.samsungmobile.com/micoach/
It’s amazing what mobile phones can do nowadays. This one doesn’t just allow you to make calls and send texts - it is also a personal trainer. Log on to the phone’s dedicated website, upload fitness programmes, strap it on and get training. It is also a heart-rate monitor, pedometer and Mp3 player.

www.onlinepersonaltrainer.co.uk
London trainer Robert Fiteni creates a programme tailored to your needs and provides unlimited email support and advice. From £47.50 for a month’s consultation.

A failure to act on AIDS ‘represents a crime against humanity’: Julio Montaner

The 17th International AIDS Conference held recently in Mexico City ended with a speech by Julio Montaner, the new president of the International AIDS Society. Dr. Montaner, the director of the B.C. Centre for Excellence in HIV-AIDS in Vancouver, has been a world leader in research, but lately has drawn criticism for crossing the line from pure science to activism. Below is an excerpt from his controversial speech. We find ourselves at a critical juncture in the summer of 2008. Over the previous three decades, we have collectively accumulated a tremendous amount of knowledge regarding what needs to be done to effectively combat HIV at the individual and societal levels. Yet implementation flounders.

We must work diligently to overcome the ever-growing implementation gap. We must recruit, if not force, the international political leadership to achieve this goal. We must keep the pressure on the G8 leaders to follow up on their commitment to achieve universal access to prevention, care and treatment by 2010.

Let’s be perfectly clear: Failure to enact a comprehensive, sustained and multipronged attack on the pandemic represents a crime – a crime against those infected, those affected, and those susceptible. Indeed, it represents a crime against humanity.

Earlier last week [July 29], UNAIDS released the 2008 Report on the Global AIDS Epidemic. The new report points out that there are now 33 million people living with HIV/AIDS worldwide against a previous estimate of 40 million. Hardly a victory, I would say.

Dr. Julio Montaner (Henry Lin)

Dr. Julio Montaner takes questions on AIDS

“‘What other country in the world would give a poor Latino guy like me the opportunities I’ve had? It’s unbelievable really. It makes me humble and it makes me proud,’ the director of the B.C. Centre for Excellence in HIV-AIDS, said in an interview,” writes Andre Picard in Canada’s man of action ready for the world stage.

“Now he has a new job: president of the International AIDS Society, one of the most high-profile and politically charged positions in the medical world.

In a fiery speech at the AIDS conference’s closing ceremonies, Dr. Montaner called on the world to work more resolutely to combat the global epidemic of HIV-AIDS. Failure to do so, he said, is tantamount to a crime against humanity.”

Dr. Julio Montaner will take your questions - on everything from his new role as president of the International AIDS Society to the latest in AIDS research to Canada’s role in the fight against AIDS.

Dr. Julio Montaner (Henry Lin)

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